Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers
نویسندگان
چکیده
منابع مشابه
Absolute bioavailability and regional absorption of ticagrelor in healthy volunteers
OBJECTIVE Ticagrelor is a direct-acting, reversibly-binding, oral P2Y12 receptor antagonist. It demonstrates predictable, linear pharmacokinetics. Two studies were undertaken to further elucidate the absolute bioavailability of ticagrelor and its regional absorption in the gastrointestinal (GI) tract. DESIGN AND METHODS In two open-label, randomized, cross-over studies, 12 volunteers received...
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OBJECTIVES Two open-label, two-period, crossover studies in healthy volunteers were designed to determine the pharmacokinetic interactions between ticagrelor, a P2Y12 receptor antagonist, and a moderate (diltiazem) and a strong (ketoconazole) cytochrome P450 (CYP) 3A inhibitor. METHODS Seventeen volunteers received diltiazem (240 mg once daily) for 14 days. In the second study, ketoconazole (...
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The results of two independent, randomized, two-period crossover, single-center studies, conducted to assess the pharmacokinetics of ticagrelor ± aspirin, inhibition of platelet aggregation (IPA) with ticagrelor/aspirin vs. clopidogrel/aspirin, and safety, tolerability, and bleeding times are reported here. In Study A (open-label), 16 volunteers received ticagrelor (50 mg bid Days 1-5; 200 mg b...
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Background: Recently, in approach to spinal pathologies, the whole spine should be considered as a biomechanicalunit. Studies have shown the great importance of sagittal and coronal balance and the relationship between the variousparts of spine together and pelvis. Former studies have shown a close relationship between spinopelvic parametersand sagittal balance. A complete und...
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Substances existed in tobacco smoke including carcinogens, alkaloids (mainly nicotine), irritants of the respiratory tract and carbon monoxide are known responsible for a wide range of diseases and disorders. The current study was designed to investigate the hematologic effects of smoking. This study is an observational, cross-sectional investigation in which the peripheral blood erythrocytic a...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2019
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa1901778